Synthesis and in vitro antimicrobial evaluation of new 1,3,4-oxadiazoles bearing 5-chloro-2-methoxyphenyl moiety was written by Basavapatna, N. Prasanna Kumar;Kikkeri, N. Mohana;Lingappa, Mallesha;Kikkeri, P. Harish. And the article was included in International Journal of Medicinal Chemistry in 2013.Electric Literature of C8H7ClO3 This article mentions the following:
A series of new 1,3,4-oxadiazole derivatives containing 5-chloro-2-methoxy benzohydrazide moiety were synthesized by the reaction of 5-chloro-2-methoxybenzoate with different aromatic carboxylic acids. These newly synthesized compounds were characterized by FT-IR, 1H NMR, mass spectra and also by elemental anal. All the newly synthesized compounds were screened for their antibacterial and antifungal activities. Antimicrobial studies revealed that some of the compounds showed significant activity against tested strains. In the experiment, the researchers used many compounds, for example, 5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2Electric Literature of C8H7ClO3).
5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Electric Literature of C8H7ClO3
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics