3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Application of 777-44-6
Quinone Reduction by Organo-Osmium Half-Sandwich Transfer Hydrogenation Catalysts was written by Bolitho, Elizabeth M.;Worby, Nathan G.;Coverdale, James P. C.;Wolny, Juliusz A.;Schunemann, Volker;Sadler, Peter J.. And the article was included in Organometallics in 2021.Application of 777-44-6 This article mentions the following:
Organo-osmium(II) 16-electron complexes [OsII(畏6-arene)(R-PhDPEN)] (where 畏6-arene = para-cymene or biphenyl) can catalyze the reduction of prochiral ketones to optically pure alcs. in the presence of a hydride source. Such complexes can achieve the conversion of pyruvate to unnatural D-lactate in cancer cells. To improve the catalytic performance of these osmium complexes, we have introduced electron-donor and electron-acceptor substituents (R) into the para (R1) or meta (R2) positions of the chiral R-phenyl-sulfonyl-diphenylethylenediamine (R-PhDPEN) ligands and explored the reduction of quinones, potential biol. substrates, which play a major role in cellular electron transfer chains. We show that the series of [OsII(畏6-arene)(R-PhDPEN)] derivatives exhibit high turnover frequencies, enantioselectivities (>92%), and conversions (>93%) for the asym. transfer hydrogenation (ATH) of acetophenone-derived substrates and reduce duroquinone and menadione to their di-alc. derivatives Modeling of the catalysis using d. functional theory (DFT) calculations suggests a mechanism involving formic acid deprotonation assisted by the catalyst amine groups, phenyl-duroquinone stacking, hydride transfer to OsII, possible CO2 coordination, and tilting of the 畏6-arene ring, followed by hydride transfer to the quinone. These findings not only reveal subtle differences between Ru(II) and Os(II) catalysts, but also introduce potential biol. applications. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6Application of 777-44-6).
3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Application of 777-44-6
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics