Multi-component cascade reaction of 3-formylchromones: highly selective synthesis of 4,5-dihydro-[4,5′-bipyrimidin]-6(1H)-one derivatives was written by Chen, Li;Huang, Rong;Yun, Xing-Han;Hao, Tian-Hui;Yan, Sheng-Jiao. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2021.Synthetic Route of C7H8Cl2N2 This article mentions the following:
A novel protocol for the construction of highly functionalized bipyrimidine derivatives from 3-formylchromones, Et 2-(pyridine-2-yl)acetate derivatives, and amidine hydrochlorides via an interesting and considerably complex multi-component cascade reaction was developed. The cascade reaction was manifested by refluxing a mixture of the three substrates in acetonitrile or DMF along with Cs2CO3. A series of 4,5-dihydro-[4,5′-bipyrimidin]-6(1H)-ones (DBPMOs) was constructed regioselectively in suitable to excellent yields. Moreover, DBPMOs then underwent a novel, metal and oxidant-free cascade reaction to produce a series of [4,5′-bipyrimidin]-6(1H)-ones (BPMOs). The formation of the bipyrimidine derivatives was enabled by the formation of five bonds and the cleavage of one bond in one pot. This protocol can be used in the synthesis of functionalized bipyrimidine derivatives via a multi-component one-pot cascade reaction rather than multi-step reactions, which were suitable for both combinatorial and parallel syntheses of bipyrimidine derivatives In the experiment, the researchers used many compounds, for example, 2-Chloro-benzamidine hydrochloride (cas: 18637-02-0Synthetic Route of C7H8Cl2N2).
2-Chloro-benzamidine hydrochloride (cas: 18637-02-0) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Synthetic Route of C7H8Cl2N2
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics