De novo design, synthesis and pharmacological evaluation of new azaindole derivatives as dual inhibitors of Abl and Src kinases was written by Cheve, Gwenael;Bories, Cedric;Fauvel, Benedicte;Picot, Francois;Tible, Alix;Dayde-Cazals, Benedicte;Loget, Olivier;Yasri, Aziz. And the article was included in MedChemComm in 2012.Reference of 6834-42-0 This article mentions the following:
A fragment based drug design approach implemented in a MedChem-Decision platform led to the discovery of a series of 2,5-disubstituted 7-azaindole derivatives, e.g., I, as potent dual Abl and Src kinase inhibitors. Extensive structure-activity relationships and structure-based drug design studies guided the exploration of the specificity pocket within the active conformation of the ATP site of the two kinases. This led to the identification of a binding mode of the 7-azaindole core to the two kinases and the synthesis and pharmacol. evaluation of compounds that exhibit low nanomolar inhibition on both Abl and Src kinases. In the experiment, the researchers used many compounds, for example, 2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0Reference of 6834-42-0).
2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Reference of 6834-42-0
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics