PTP-1B inhibitors: Cyclopenta[d][1,2]-oxazine derivatives was written by Cho, Sung Yun;Baek, Ji Yoen;Han, Sang Sub;Kang, Seung Kyu;Ha, Jae Du;Ahn, Jin Hee;Lee, Jae Don;Kim, Kwang Rok;Cheon, Hyae Gyeong;Rhee, Sang Dal;Yang, Sung Don;Yon, Gyu Hwan;Pak, Chwang Siek;Choi, Joong-Kwon. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2006.Name: 3-Cyanobenzoyl chloride This article mentions the following:
A series of novel cyclopenta[d][1,2]-oxazine derivatives was prepared and evaluated for their inhibitory activity toward protein tyrosine phosphatase 1B (PTP-1B). Compound 6s (I)was found to be an inhibitor of PTP-1B with nanomolar IC50 value and high level of selectivity over other recombinant phosphatases. In the experiment, the researchers used many compounds, for example, 3-Cyanobenzoyl chloride (cas: 1711-11-1Name: 3-Cyanobenzoyl chloride).
3-Cyanobenzoyl chloride (cas: 1711-11-1) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Name: 3-Cyanobenzoyl chloride
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics