Furanyl-1,3-thiazol-2-yl and benzoxazol-5-ylacetic acid derivatives: novel classes of heparanase inhibitor was written by Courtney, Stephen M.;Hay, Philip A.;Buck, Richard T.;Colville, Claire S.;Phillips, David J.;Scopes, David I. C.;Pollard, Faye C.;Page, Martin J.;Bennett, James M.;Hircock, Margaret L.;McKenzie, Edward A.;Bhaman, Maina;Felix, Robert;Stubberfield, Colin R.;Turner, Paul R.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2005.Product Details of 1711-11-1 This article mentions the following:
Using a furanylthiazoleacetic acid as a starting point, a novel series of benzoxazol-5-ylacetic acid derivatives have been identified as heparanase inhibitors. Several compounds, such as I, possess an IC50 of 鈭?00 nM against heparanase. Several of the compounds show antiangiogenic properties. Improvement to the DMPK profile has provided compounds of potential use in in vivo models. In the experiment, the researchers used many compounds, for example, 3-Cyanobenzoyl chloride (cas: 1711-11-1Product Details of 1711-11-1).
3-Cyanobenzoyl chloride (cas: 1711-11-1) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Product Details of 1711-11-1
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics