para-Selective Arylation of Arenes: A Direct Route to Biaryls by Norbornene Relay Palladation was written by Dutta, Uttam;Porey, Sandip;Pimparkar, Sandeep;Mandal, Astam;Grover, Jagrit;Koodan, Adithyaraj;Maiti, Debabrata. And the article was included in Angewandte Chemie, International Edition in 2020.Electric Literature of C7H5ClF2 This article mentions the following:
Biaryl compounds are extremely important structural motifs in natural products, biol. active components and pharmaceuticals. Selective synthesis of biaryls by distinguishing the subtle reactivity difference of distal arene C-H bonds are significantly challenging. Herein, we describe para-selective C-H arylation, which is acheived by a unique combination of a meta-directing group and norbornene as a transient mediator. Upon direct meta-C-H palladation, one-bond relay palladation occurs in presence of norbornene and subsequently para-C-H arylation is achieved for sulfonates, phosphonates and phenols bearing 2,6-disubstitution patterns. The protocol is amenable to electron-deficient aryl iodides. Multisubstituted arenes and phenols are obtained by postsynthetic modification of the products. The protocol allows the synthesis of hexa-substituted benzene by sequential selective distal C-H functionalization. In the experiment, the researchers used many compounds, for example, 2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4Electric Literature of C7H5ClF2).
2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Electric Literature of C7H5ClF2
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics