Benzimidazole-based compounds kill Mycobacterium tuberculosis was written by Gong, Yaling;Somersan Karakaya, Selin;Guo, Xiaoyong;Zheng, Purong;Gold, Ben;Ma, Yao;Little, David;Roberts, Julia;Warrier, Thulasi;Jiang, Xiuju;Pingle, Maneesh;Nathan, Carl F.;Liu, Gang. And the article was included in European Journal of Medicinal Chemistry in 2014.Safety of 3-Cyanobenzoyl chloride This article mentions the following:
Tuberculosis remains one of the deadliest infectious diseases, killing 1.4 million people annually and showing a rapid increase in cases resistant to multiple drugs. New antibiotics against tuberculosis are urgently needed. Here the authors describe the design, synthesis and structure-activity relationships of a series of benzimidazole-based compounds, e.g. I [R1 = Me, cyclobutyl, t-Bu, etc.; R2 = morpholin-4-yl, thiomorpholin-4-yl; R3 = H, Me] with activity against Mycobacterium tuberculosis in a replicating state, a physiol.-induced nonreplicating state, or both. Several compounds, which shared a 5-nitrofuranyl moiety, exhibited high potency and acceptable selectivity indexes (SI). As illustrated by compound I [R1 = isopentyl, R2 = morpholin-4-yl, R3 = Me] (MIC90 < 0.049 渭g/mL, SI > 512), the 5-nitrofuranyl group was compatible with minimal cytotoxicity and good intramacrophage killing, although it lacked nonreplicating activity when assessed by CFU assays. Compound I [R1 = isopentyl, R2 = morpholin-4-yl, R3 = Me] had low mutagenic potential by SOS Chromotest assay, making this class of compounds good candidates for further evaluation and target identification. In the experiment, the researchers used many compounds, for example, 3-Cyanobenzoyl chloride (cas: 1711-11-1Safety of 3-Cyanobenzoyl chloride).
3-Cyanobenzoyl chloride (cas: 1711-11-1) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Safety of 3-Cyanobenzoyl chloride
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics