Arenesulfonic acid derivatives. XI. Synthesis of sulfonamides, hydrazides, and ureas containing a benzofuran moiety was written by Kaldrikyan, M. A.;Geboyan, V. A.;Aroyan, A. A.;Stepanyan, N. O.;Sapondzyan, L. G.;Sarkisyan, L. M.. And the article was included in Armyanskii Khimicheskii Zhurnal in 1980.Synthetic Route of C10H13ClO3S This article mentions the following:
Sixteen amides I (R, R1 = Me, Et, Pr, Bu) were obtained in 61-91% yield by reaction of p-ROC6H4SO2Cl (II) with the corresponding benzofuranylalkylamine. Treatment of 2-benzofurancarboxylic hydrazide with II gave 72-80% III, which could also be obtained using the benzofurancarbonyl chloride and p-ROC6H4SO2NHNH2. Eight IV (R = Me, Et, Pr, Bu; R1 = Me, Et) were obtained in 45-74% yield by reaction of p-ROC6H4SO2NHCO2Et with the corresponding benzofuranylalkylamine. The hypoglycemic and anticonvulsive properties of I, III and IV were determined; none exhibited anticonvulsive properties and I (R = R1 = Pr) reduced blood glucose content by 20% at 250 mg/kg. All the remaining compounds exhibited hyperglycemic activity. In the experiment, the researchers used many compounds, for example, 4-Butoxybenzene-1-sulfonyl chloride (cas: 1138-56-3Synthetic Route of C10H13ClO3S).
4-Butoxybenzene-1-sulfonyl chloride (cas: 1138-56-3) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Synthetic Route of C10H13ClO3S
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics