Acyl/aroyl Meldrum’s acid as an enol surrogate for the direct organocatalytic synthesis of 伪,尾-unsaturated ketones was written by Khopade, Tushar M.;Warghude, Prakash K.;Mete, Trimbak B.;Bhat, Ramakrishna G.. And the article was included in Tetrahedron Letters in 2019.Reference of 5344-49-0 This article mentions the following:
The operationally simple, robust and straightforward organocatalytic protocol is developed for the synthesis of E-selective 伪,尾-unsaturated ketones. The method utilizes simple and easily accessible starting materials such as Meldrum’s acid, carboxylic acid, aldehyde and simple bifunctional amine catalyst. The tandem organocatalytic process utilizes acyl/aroyl Meldrum’s acid as an enol surrogate for the effective Doebner-Knoevenagel type condensation reactions. A wide variety of aldehydes, carboxylic acids and base sensitive functional groups are well tolerated under the mild reaction conditions. In the experiment, the researchers used many compounds, for example, 2-Chloro-6-nitrobenzoic acid (cas: 5344-49-0Reference of 5344-49-0).
2-Chloro-6-nitrobenzoic acid (cas: 5344-49-0) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Reference of 5344-49-0
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics