Reactivity of functionalized arylcarbenes. 2-Phenylethyl side chains and hetero analogs was written by Kirmse, Wolfgang;Konrad, Wolfgang;Ozkir, Ismail S.. And the article was included in Tetrahedron in 1997.SDS of cas: 7476-66-6 This article mentions the following:
Phenylcarbenes with -X-CH2Ph and -CH2X-Ph (X = CH2, O, SiMe2) groups in the ortho position were generated thermally and photolytically from diazo or tosylhydrazone precursors. Stereorandom insertion reactions with 尾-C-H bonds were observed, pointing to a triplet abstraction-recombination mechanism. Large kinetic and stereochem. deuterium isotope effects support this notion. The ample formation of benzocyclobutenes from 2-CH2-X-Ph substrates is due to insertion of the carbenes into ArCH2-X bonds. Addition to the terminal Ph groups competes with C-H and C-X insertion. The results of benzophenone sensitization and of trapping with methanol suggest that the intramol. reactions of functionalized arylcarbenes proceed, at best, competitively with spin inversion. In the experiment, the researchers used many compounds, for example, Methyl 2-chloro-2-phenylacetate (cas: 7476-66-6SDS of cas: 7476-66-6).
Methyl 2-chloro-2-phenylacetate (cas: 7476-66-6) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.SDS of cas: 7476-66-6
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics