An approach to 1-alkyl-3-phenylpiperidine derivatives containing 2,5-functionalized groups: 1-methyl-2-(4-chlorophenylthiomethyl)-3-(3-methoxyphenyl)-5-(methoxycarbonyl)piperidine was written by Kotzamani, Heleni K.;Gourdoupis, Christos G.;Stamos, Ioannis K.. And the article was included in Tetrahedron in 1994.Reference of 6834-42-0 This article mentions the following:
3-MeOC6H4CH2COCH2SC6H4Cl-4 (I) was synthesized by regiospecific addition of 4-chlorothiophenol to diazoketone 3-MeOC6H4CH2COCHN2 in the presence of a rhodium(II) acetate catalyst. Annulation of I with the enamine prepared from MeNH2 and CH2:C(CH2Br)CO2Me gave a tetrahydropyridine derivative Reduction of this compound with sodium cyanoborohydride in the presence of carboxylic acid produced the title compound In the experiment, the researchers used many compounds, for example, 2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0Reference of 6834-42-0).
2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Reference of 6834-42-0
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics