Synthesis and biological evaluation of 20-epi-amino-20-deoxysalinomycin derivatives was written by Li, Yu;Shi, Qiuyan;Shao, Jiajia;Yuan, Yaping;Yang, Zhigang;Chen, Shizhen;Zhou, Xin;Wen, Shijun;Jiang, Zhong-Xing. And the article was included in European Journal of Medicinal Chemistry in 2018.HPLC of Formula: 1711-11-1 This article mentions the following:
To improve the druggability of salinomycin, a 20-epi-amino-20-deoxysalinomycin derivatives library was synthesized with high efficacy from which a few salinomycin derivatives with high potency and selectivity were identified through comprehensive cytotoxicity assay, including a fluorine-19 magnetic resonance sensitive tool mol. Using a K-ras cellular model, salinomycin and its derivatives showed different mol. mode of action from literature reports. These results would be valuable for developing salinomycin-based cancer therapy. In the experiment, the researchers used many compounds, for example, 3-Cyanobenzoyl chloride (cas: 1711-11-1HPLC of Formula: 1711-11-1).
3-Cyanobenzoyl chloride (cas: 1711-11-1) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.HPLC of Formula: 1711-11-1
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics