Synthesis of isothiocyanates by reaction of amines with phenyl chlorothionoformate via one-pot or two-step process was written by Li, Zheng-Yi;Ma, Hong-Zhao;Han, Chen;Xi, Hai-Tao;Meng, Qi;Chen, Xin;Sun, Xiao-Qiang. And the article was included in Synthesis in 2013.Electric Literature of C7H3Cl2NS This article mentions the following:
A facile and efficient synthesis of isothiocyanates from amines is described. This method involves the reaction of amines with Ph chlorothionoformate in the presence of solid NaOH by either a one-pot process or a two-step approach. The one-pot process is useful for preparing alkyl and electron-rich aryl isothiocyanates, whereas the two-step approach is more versatile, working very well not only for alkyl and electron-rich aryl isothiocyanates, but also for highly electron-deficient aryl and heterocyclic isothiocyanates. In the experiment, the researchers used many compounds, for example, 2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1Electric Literature of C7H3Cl2NS).
2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Electric Literature of C7H3Cl2NS
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics