Synthesis of tosufloxacin p-tosylate was written by Liu, Mingliang;Sun, Lanying;Wei, Yonggang;Guo, Huiyuan. And the article was included in Zhongguo Yiyao Gongye Zazhi in 2003.Safety of Ethyl 3-(2,6-Dichloro-5-fluoro-3-pyridyl)-3-oxopropionate This article mentions the following:
The title compound was prepared from Et 2,6-dichloro-5-fluoronicotinoylacetate via condensation with CH(OEt)3, 2,4-difluoroaniline displacement, cyclization, condensation with 3-aminopyrrolidine and hydrolysis in overall yield 72.6%. In the experiment, the researchers used many compounds, for example, Ethyl 3-(2,6-Dichloro-5-fluoro-3-pyridyl)-3-oxopropionate (cas: 96568-04-6Safety of Ethyl 3-(2,6-Dichloro-5-fluoro-3-pyridyl)-3-oxopropionate).
Ethyl 3-(2,6-Dichloro-5-fluoro-3-pyridyl)-3-oxopropionate (cas: 96568-04-6) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Safety of Ethyl 3-(2,6-Dichloro-5-fluoro-3-pyridyl)-3-oxopropionate
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics