Chemical and Genetic Engineering of Selective Ion Channel-Ligand Interactions was written by Magnus, Christopher J.;Lee, Peter H.;Atasoy, Deniz;Su, Helen H.;Looger, Loren L.;Sternson, Scott M.. And the article was included in Science (Washington, DC, United States) in 2011.Category: chlorides-buliding-blocks This article mentions the following:
Ionic flux mediates essential physiol. and behavioral functions in defined cell populations. Cell type-specific activators of diverse ionic conductances are needed for probing these effects. We combined chem. and protein engineering to enable the systematic creation of a toolbox of ligand-gated ion channels (LGICs) with orthogonal pharmacol. selectivity and divergent functional properties. The LGICs and their small-mol. effectors were able to activate a range of ionic conductances in genetically specified cell types. LGICs constructed for neuronal perturbation could be used to selectively manipulate neuron activity in mammalian brains in vivo. The diversity of ion channel tools accessible from this approach will be useful for examining the relationship between neuronal activity and animal behavior, as well as for cell biol. and physiol. applications requiring chem. control of ion conductance. In the experiment, the researchers used many compounds, for example, 5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2Category: chlorides-buliding-blocks).
5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Category: chlorides-buliding-blocks
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics