Preparation of 2,6-difluoro-n-alkylbenzenes from 1,3-difluorobenzene. Transformation of 2,6-difluorotoluene to the corresponding benzaldehyde via benzyl chloride was written by Malykhin, Evghenii V.;Shteingarts, Vitalii D.. And the article was included in Journal of Fluorine Chemistry in 1998.SDS of cas: 697-73-4 This article mentions the following:
Reactions of n-alkyl chlorides with the 2,6-difluorophenyl anion, prepared from 1,3-difluorobenzene by the action of sodium amide in liquid ammonia, give 2,6-difluoro-n-alkylbenzenes in high yields. 2,6-Difluorotoluene reacts with chlorine at 80掳 to give 2,6-difluorobenzyl chloride in 92% yield. 2,6-Difluorobenzaldehyde has been obtained from this chloride through Sommelet’s reaction in 62% yield. In the experiment, the researchers used many compounds, for example, 2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4SDS of cas: 697-73-4).
2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.SDS of cas: 697-73-4
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics