Structure-activity evaluation of new uracil-based non-nucleoside inhibitors of HIV reverse transcriptase was written by Matyugina, Elena S.;Valuev-Elliston, Vladimir T.;Geisman, Alexander N.;Novikov, Mikhail S.;Chizhov, Alexander O.;Kochetkov, Sergey N.;Seley-Radtke, Katherine L.;Khandazhinskaya, Anastasia L.. And the article was included in MedChemComm in 2013.Reference of 1711-11-1 This article mentions the following:
A new series of potential nonnucleoside inhibitors of HIV-1 reverse transcriptase (NNRTIs) based on the carbocyclic 5′-nor-uracil scaffold were designed and synthesized. Three different aspects of the scaffold were investigated: the effects of adding a linker between the carbocyclic and Ph fragments, introduction of different substituents on the benzoyl residue and replacing the central carbocyclic ring with a benzyl group. Analogs of 2′,3′-dideoxy-2′,3′-didehydro-5′-nor-uridine, bearing 3,5-dichloro- or 3,5-dimethylbenzoyl groups, showed inhibitory activity against HIV-RT wild-type (IC50 5-10 渭M) and mutants L100I (IC50 1.2-2.1 渭M) and K103N (IC50 8-17 渭M). In the experiment, the researchers used many compounds, for example, 3-Cyanobenzoyl chloride (cas: 1711-11-1Reference of 1711-11-1).
3-Cyanobenzoyl chloride (cas: 1711-11-1) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Reference of 1711-11-1
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics