2-(1-Adamantyl)-1-{4-[(2-chloro-9-isopropyl-9H-purin-6-yl)aminomethyl]phenyl}ethanone was written by Rouchal, Michal;Necas, Marek;Pires de Carvalho, Fabiana;Vicha, Robert. And the article was included in Acta Crystallographica, Section E: Structure Reports Online in 2009.Synthetic Route of C8H8Cl2N4 This article mentions the following:
The structure of the title compound, C27H32ClN5O, consists of two crystallog. independent conformers differing slightly in all geometric parameters. Both contain nearly planar purine and benzene ring systems [maximum deviations of 0.046 (3) and 0.005 (2) 脜, resp.], the dihedral angles between them being 76.44 (6) and 82.39 (6)掳, and an adamantane cage consisting of three fused cyclohexane rings in almost ideal chair conformations, with C-C-C angles in the range 108.7 (2)-110.6 (2)掳. The carbonyl plane and the benzene ring are almost coplanar [dihedral angles of 6.43 (9) and 0.64 (8)掳 in the two conformers]. The crystal structure is stabilized by intermol. N-H…N interactions that link adjacent mols. into dimers and by some non-bonding contacts of the C-H…Cl type. Crystallog. data are given. In the experiment, the researchers used many compounds, for example, 2,6-Dichloro-9-isopropyl-9H-purine (cas: 203436-45-7Synthetic Route of C8H8Cl2N4).
2,6-Dichloro-9-isopropyl-9H-purine (cas: 203436-45-7) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Synthetic Route of C8H8Cl2N4
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics