Synthesis, characterization and in vitro cytotoxicity of the first palladium(II) oxalato complexes involving adenine-based ligands was written by Starha, Pavel;Travnicek, Zdenek;Popa, Igor. And the article was included in Journal of Inorganic Biochemistry in 2009.COA of Formula: C8H8Cl2N4 This article mentions the following:
The 1st [Pd(Ln)2(ox)]xH2O oxalato (ox) complexes involving 2-chloro-N6-(benzyl)-9-isopropyladenine (L1; complex 1), 2-chloro-N6-(4-methoxybenzyl)-9-isopropyladenine (L2; 2), 2-chloro-N6-(2,3-dimethoxybenzyl)-9-isopropyladenine (L3; 3), 2-chloro-N6-(2,4-dimethoxybenzyl)-9-isopropyladenine (L4; 4), and 2-chloro-N6-(4-methylbenzyl)-9-isopropyladenine (L5; 5) were synthesized by the reactions of potassium bis(oxalato)palladate(II) dihydrate, [K2Pd(ox)2]路2H2O, with the mentioned organic compounds (H2ox = oxalic acid; x = 0 for 1–3 and 5 or 2 for 4). Elemental analyses (C, H, N), FTIR, Raman and NMR (1H, 13C, 15N) spectroscopies, conductivity measurements and thermal studies (TGA and DTA, TG/DTA) were used to characterize the prepared complexes. The mol. structures of [Pd(L2)2(ox)] (2) and [Pd(L5)2(ox)]路L5路Me2CO (5路L5路Me2CO) were determined by a single crystal x-ray anal. The geometry of these complexes is slightly distorted square-planar with two appropriate Ln (n = 2 or 5) mols. mutually arranged in the head-to-head (2) or head-to-tail (5) orientation. The Ln ligands are coordinated to the central Pd(II) ion via the N7 atoms. The same conclusions regarding the binding properties of L1-L5 ligands can be made based on multinuclear NMR spectra. In vitro cytotoxicity of the complexes 1–5 was evaluated against human chronic myelogenous leukemia (K562) and human breast adenocarcinoma (MCF7) cancer cell lines. Significant cytotoxicity was determined for the complexes 3 (IC50 = 6.2 渭M) and 5 (IC50 = 6.8 渭M) on the MCF7 cell line, which is even better than that found for the known and widely-used platinum-bearing antineoplastic drugs, i.e. oxaliplatin and cisplatin. In the experiment, the researchers used many compounds, for example, 2,6-Dichloro-9-isopropyl-9H-purine (cas: 203436-45-7COA of Formula: C8H8Cl2N4).
2,6-Dichloro-9-isopropyl-9H-purine (cas: 203436-45-7) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.COA of Formula: C8H8Cl2N4
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics