Designing New Analogs for Streamlining the Structure of Cytotoxic Lamellarin Natural Products was written by Tangdenpaisal, Kassrin;Worayuthakarn, Rattana;Karnkla, Supatra;Ploypradith, Poonsakdi;Intachote, Pakamas;Sengsai, Suchada;Saimanee, Busakorn;Ruchirawat, Somsak;Chittchang, Montakarn. And the article was included in Chemistry – An Asian Journal in 2015.Application In Synthesis of 2-(3-Methoxyphenyl)acetyl chloride This article mentions the following:
Despite the therapeutic potential of marine-derived lamellarin natural products, their preclin. development has been hampered by their lipophilic nature, causing very poor aqueous solubility In order to develop more drug-like analogs, their structure was streamlined in this study from both the cytotoxic activity and lipophilicity standpoints. First, a modified total synthetic route was successfully devised to construct a library of 59 systematically designed lamellarin analogs, which were then subjected to cytotoxicity and log P determinations [e.g., I with single or double bond as indicated by dotted line; R = H, Me; X = H, OH; Y = H, OMe; A, B = H, OH]. Along with the 25 first-generation lamellarins previously synthesized in our laboratory, the structure-activity and structure-lipophilicity relationships were extensively evaluated. Our results clearly indicated the addnl. structural requirements around the lamellarin skeleton which, when combined with those reported previously, can provide invaluable guidance for further modifications to increase the aqueous solubility of these compounds In the experiment, the researchers used many compounds, for example, 2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0Application In Synthesis of 2-(3-Methoxyphenyl)acetyl chloride).
2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Application In Synthesis of 2-(3-Methoxyphenyl)acetyl chloride
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics