Inhibition of biofilm formation by amphiphilic star polymer coatings was written by Totani, Masayasu;Lan, Xiuwan;Wu, Jianfeng;Xi, Chuanwu;Kuroda, Kenichi;Ando, Tsuyoshi;Terada, Kayo;Hirohara, Shiho;Tanihara, Masao. And the article was included in PMSE Preprints in 2012.Synthetic Route of C9H9ClO2 This article mentions the following:
Bacterial infections related to medical implants are a significant problem, causing serious complications after surgery and may lead to implant failure. These infections are associated with adhesion of bacteria to and colonization on implant surfaces, resulting in biofilm formations. Hydrophilic surfaces as a result of polymer coatings have shown potential in preventing biofilm formation. To that end, we have demonstrated a new strategy to prepare implant surfaces with a high d. of hydrophilic polymers utilizing star polymer architectures. The synthesis of these star polymers contain both hydrophilic [poly(2-hydroxyethyl methacrylate)] and hydrophobic [poly(Me methacrylate)] arms will be described. Addnl., results of the anti-biofilm activity against Escherichia coli by these polymer coatings will be presented. In the experiment, the researchers used many compounds, for example, Methyl 2-chloro-2-phenylacetate (cas: 7476-66-6Synthetic Route of C9H9ClO2).
Methyl 2-chloro-2-phenylacetate (cas: 7476-66-6) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Synthetic Route of C9H9ClO2
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics