Wang, Tianyu et al. published their research in Journal of Medicinal Chemistry in 2021 | CAS: 65515-32-4

Methyl 6-chloro-2-methoxynicotinate (cas: 65515-32-4) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Reference of 65515-32-4

Novel Biphenyl Pyridines as Potent Small-Molecule Inhibitors Targeting the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Interaction was written by Wang, Tianyu;Cai, Shi;Wang, Mingming;Zhang, Wanheng;Zhang, Kuojun;Chen, Dong;Li, Zheng;Jiang, Sheng. And the article was included in Journal of Medicinal Chemistry in 2021.Reference of 65515-32-4 This article mentions the following:

The design, synthesis and in-vitro and in-vivo evaluation of a series of novel biphenyl pyridines, I [R = Ph, 3-methoxyphenyl, 1,3-benzodioxol-5-yl, etc.; R1 = H, (2-hydroxyethylamino)methyl; R2 = methoxycarbonyl, (2-hydroxyethylamino)methyl, [[(2S)-5-oxopyrrolidin-2-yl]methylamino]methyl, etc.; R3 = H, MeO] as the inhibitors of PD-1/PD-L1 was reported. Compound I [R = Ph, R1 = H, R2 = (2-hydroxyethylamino)methyl, R3 = MeO] was found to inhibit the PD-1/PD-L1 interaction with an IC50 value of 3.8 卤 0.3 nM and enhance the killing activity of tumor cells by immune cells. Compound I [R = Ph, R1 = H, R2 = (2-hydroxyethylamino)methyl, R3 = MeO] displayed great pharmacokinetics (oral bioavailability of 22%) and significant in-vivo antitumor activity in a CT26 mouse model. Flow cytometry and immunohistochem. data indicated that compound I [R = Ph, R1 = H, R2 = (2-hydroxyethylamino)methyl, R3 = MeO] activates the immune activity in tumors. These results suggest that compound I [R = Ph, R1 = H, R2 = (2-hydroxyethylamino)methyl, R3 = MeO] is a promising small-mol. inhibitor against the PD-1/PD-L1 axis and merits further development. In the experiment, the researchers used many compounds, for example, Methyl 6-chloro-2-methoxynicotinate (cas: 65515-32-4Reference of 65515-32-4).

Methyl 6-chloro-2-methoxynicotinate (cas: 65515-32-4) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Reference of 65515-32-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics