Palladium-Catalyzed Thiocarbonylation of Benzyl Chlorides with Sulfonyl Chlorides for the Synthesis of Arylacetyl Thioesters was written by Wang, Wei;Qi, Xinxin;Wu, Xiao-Feng. And the article was included in Advanced Synthesis & Catalysis in 2021.Name: 1-(Chloromethyl)-3-methylbenzene This article mentions the following:
A convenient procedure for the synthesis of thioesters RCH2C(O)SR1 (R = Ph, 3,4-dimethylphenyl, naphthalen-1-yl, thiophen-3-yl, etc.; R1 = Ph, 2,4,6-trimethylphenyl, naphthalen-1-yl, etc.) has been developed via a palladium-catalyzed thiocarbonylation of benzyl chlorides RCH2Cl with sulfonyl chlorides R1S(O)2Cl. Various arylacetyl thioesters were produced in good yields by using sulfonyl chlorides as an odorless sulfur source. Furthermore, W(CO)6 exhibited dual roles as both a solid CO surrogate and reductant here. In the experiment, the researchers used many compounds, for example, 1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9Name: 1-(Chloromethyl)-3-methylbenzene).
1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Name: 1-(Chloromethyl)-3-methylbenzene
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics