Design, synthesis and structure-activity relationships of azole acids as novel, potent dual PPAR 伪/纬 agonists was written by Zhang, Hao;Ryono, Denis E.;Devasthale, Pratik;Wang, Wei;O’Malley, Kevin;Farrelly, Dennis;Gu, Liqun;Harrity, Thomas;Cap, Michael;Chu, Cuixia;Locke, Kenneth;Zhang, Litao;Lippy, Jonathan;Kunselman, Lori;Morgan, Nathan;Flynn, Neil;Moore, Lisa;Hosagrahara, Vinayak;Zhang, Lisa;Kadiyala, Pathanjali;Xu, Carrie;Doweyko, Arthur M.;Bell, Aneka;Chang, Chiehying;Muckelbauer, Jodi;Zahler, Robert;Hariharan, Narayanan;Cheng, Peter T. W.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2009.Application In Synthesis of 2-(3-Methoxyphenyl)acetyl chloride This article mentions the following:
The design, synthesis and structure-activity relationships of a novel series of N-phenyl-substituted pyrrole I [R1 = 3- or 4-[2-(5-Me-2-Ph-4-oxazolyl)ethoxy], R2 = Me, Ph], 1,2-pyrazole and 1,2,3-triazole acid analogs as PPAR ligands was outlined. The triazole acid analogs II [R1 = 3- (III) or 4-[2-(5-Me-2-Ph-4-oxazolyl)ethoxy]] were identified as potent dual PPAR伪/纬 agonists both in binding and functional assays in vitro. Analog III showed excellent glucose and triglyceride lowering in diabetic db/db mice. In the experiment, the researchers used many compounds, for example, 2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0Application In Synthesis of 2-(3-Methoxyphenyl)acetyl chloride).
2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Application In Synthesis of 2-(3-Methoxyphenyl)acetyl chloride
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics