The synthesis and antistaphylococcal activity of N-sulfonaminoethyloxime derivatives of dehydroabietic acid was written by Zhang, Wen-Ming;Yao, Yang;Yang, Teng;Wang, Xue-Ying;Zhu, Zhen-Yun;Xu, Wen-Tao;Lin, Hai-Xia;Gao, Zhao-Bing;Zhou, Hu;Yang, Cai-Guang;Cui, Yong-Mei. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2018.Computed Properties of C7H4ClF3O2S This article mentions the following:
A series of N-sulfonaminoethyloxime derivatives of dehydroabietic acid were synthesized and investigated for their antibacterial activity against Staphylococcus aureus Newman strain and multidrug-resistant strains (NRS-1, NRS-70, NRS-100, NRS-108 and NRS-271). Most of the target compounds having chloro, bromo, trifluoromethyl Ph moiety exhibited potent in vitro antistaphylococcal activity. The meta-CF3 Ph derivative T23 showed the highest activity with MIC of 0.390.78 渭g/mL against S. aureus Newman, while several analogs showed similar potent antibacterial activity with MIC values between 0.78 and 1.56 渭g/mL against fve multidrug-resistant S. aureus. The stability of T35 in plasma of SD rat and the cellular cytotoxicity were also evaluated. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6Computed Properties of C7H4ClF3O2S).
3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Computed Properties of C7H4ClF3O2S
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics