Cyclic amine sulfonamides as linkers in the design and synthesis of novel human 尾3 adrenergic receptor agonists was written by Sum, Fuk-Wah;Wong, Victoria;Han, Stella;Largis, Elwood;Mulvey, Ruth;Tillett, Jeff. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2003.Application of 1138-56-3 This article mentions the following:
Piperidine, pyrrolidine, and azetidine sulfonamides were examined as linkers in designing novel human 尾3 adrenergic receptor (尾3-AR) agonists. The azetidine derivative, and piperidine derivatives were found to be potent 尾3-AR agonists and have good selectivity against 尾1– and 尾2-AR. In the experiment, the researchers used many compounds, for example, 4-Butoxybenzene-1-sulfonyl chloride (cas: 1138-56-3Application of 1138-56-3).
4-Butoxybenzene-1-sulfonyl chloride (cas: 1138-56-3) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Application of 1138-56-3
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics