A Three-Component Approach to 3,5-Diaryl-1,2,4-thiadiazoles under Transition-Metal-Free Conditions was written by Xie, Hao;Cai, Jinhui;Wang, Zilong;Huang, Huawen;Deng, Guo-Jun. And the article was included in Organic Letters in 2016.Application In Synthesis of 2-Chloro-benzamidine hydrochloride This article mentions the following:
A novel route is disclosed for the synthesis of 1,2,4-thiadiazoles starting from amidines, elemental sulfur, and 2-methylquinolines or aldehydes under transition-metal-free conditions. This three-component approach affords efficient and rapid access to 3,5-diaryl substituted 1,2,4-thiadiazoles with good tolerance of a broad range of functional groups. Mechanistic studies reveal a radical-involved pathway. In the experiment, the researchers used many compounds, for example, 2-Chloro-benzamidine hydrochloride (cas: 18637-02-0Application In Synthesis of 2-Chloro-benzamidine hydrochloride).
2-Chloro-benzamidine hydrochloride (cas: 18637-02-0) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Application In Synthesis of 2-Chloro-benzamidine hydrochloride
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics