Kinetics of oxidation of substituted 纬-ketoacid by N-chlorosaccharin in aqueous acetic acid medium was written by Farook, N. A. Mohamed;Alhaji, N. M. I.. And the article was included in International Journal of Chemical Sciences in 2004.Synthetic Route of C7H4ClNO3S This article mentions the following:
The kinetics of oxidation of a 纬-ketoacid namely, 4-oxo-4-(3′-4′-dimethylphenyl)butanoic acid by N-chlorosaccharin in aqueous acetic acid medium in the presence of perchloric acid have been investigated potentiometrically. The observed rate of oxidation is first order each in [KA], [NCSA] and [H+]. The main product of the oxidation is 3,4-dimethylbenzoic acid. The rate decreases with the addition of saccharin, one of the products of the reaction. Variation in ionic strength of the reaction medium has no significant effect on the rate of oxidation, but the rate of the reaction is enhanced by lowering the dielec. constant of the reaction medium. Hypochlorous acidium ion (H2O+Cl), has been postulated as the reactive oxidizing species. A suitable mechanism consistent with the exptl. results has been proposed. The activation parameters have been computed with respect to slow step of the mechanism. In the experiment, the researchers used many compounds, for example, 2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide (cas: 14070-51-0Synthetic Route of C7H4ClNO3S).
2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide (cas: 14070-51-0) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Synthetic Route of C7H4ClNO3S
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics