Kinetics of hydrolysis of 伪-chloroalkyl benzoates was written by Euranto, Erkki K.;Yrjana, Torsti. And the article was included in Suomen Kemistilehti B in 1965.Electric Literature of C8H7ClO2 This article mentions the following:
The kinetics of the hydrolysis of chloromethyl benzoate (I) and 伪-chloroethyl benzoate (II) in dioxane-water mixtures was investigated. The main reaction in both cases was a nucleophilic displacement of the Cl, which took place by the unimol. SN1 mechanism in the case of II and by the bimol. SN2 mechanism in the case of I as indicated by the approx. 100 times higher rate of hydrolysis of II, by the different solvent and salt effects, and by the values of the Arrhenius parameters. For 75% dioxane-water at 25掳, E0 for the uncatalyzed hydrolysis was 22.00 卤 0.008 and 20.20 卤 0.20 kcal./mole for I and II, resp. In the experiment, the researchers used many compounds, for example, Chloromethyl benzoate (cas: 5335-05-7Electric Literature of C8H7ClO2).
Chloromethyl benzoate (cas: 5335-05-7) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Electric Literature of C8H7ClO2
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics