Lopez Zavala, Miguel Angel; Reynoso-Cuevas, Liliana published the artcile< Simultaneous extraction and determination of four different groups of pharmaceuticals in compost using optimized ultrasonic extraction and ultrahigh pressure liquid chromatography-mass spectrometry>, Reference of 6055-19-2, the main research area is group pharmaceutical compost optimized ultrasonic ultrahigh pressure liquid chromatog; compost pharmaceuticals ultrasonic extraction USE UHPLC MS MS; Compost; Pharmaceuticals; UHPLC–MS/MS; Ultrasonic extraction (USE).
An anal. method for the simultaneous extraction and determination of four different groups of pharmaceuticals in compost from the biodegradation of biol. infectious hazardous wastes (BIHW) was developed and successfully validated. Compost samples were spiked with known concentrations of the pharmaceuticals of interest. Ultrasonic extraction with an Et acetate and methanol solution (1:1) resulted to be effective for the extraction of eight target compounds All the compounds were separated in a single gradient run by UHPLC using a Zorbax SB C18 Agilent (2.1 × 50 mm, 1.8 μm) column. Analytes were detected and quantified via multiple reaction monitoring (MRM) using an AB SCIEX API-5000TM triple quadrupole with electrospray ionization (ESI) in pos. mode. The optimum mobile phase consisted of ammonium formate (2 mM, pH 3): MeOH (50:50). Recovery values of the ultrasonic extraction for all compounds were on the order of 87% to 113% with absolute deviations lower than 11%. The limits of detection and quantification for the eight pharmaceuticals were on the order of 0.66 ng g-1 and 2 ng g-1 resp. for all the pharmaceuticals analyzed. These values are lower than those values reported in the literature. Suitable level of linearity, acceptable limits of detection and quantification, good repeatability and inter-day precision, non-ion interference, and low matrix effect resulted from the validation of the anal. method. Implementation of the anal. procedure proposed in this research will contribute in having shorter anal. time and lower costs when working with complex matrixes such as compost.
Journal of Chromatography A published new progress about Antibiotics. 6055-19-2 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H17Cl2N2O3P, Reference of 6055-19-2.
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