Chevreuil, Francis; Landreau, Anne; Seraphin, Denis; Larcher, Gerald; Bouchara, Jean-Philippe; Richomme, Pascal published the artcile< Synthesis and antifungal activity of new thienyl and aryl conazoles>, HPLC of Formula: 19995-38-1, the main research area is fungicide synthesis thienyl aryl conazole Candida Apergillus resistance.
Recent studies reported that a first generation azole (tioconazole) was active against Candida glabrata petite mutants, a fluconazole- and voriconazole- resistant strain of fungi characterized as most azole resistant yeast by an overexpression of the efflux pumps. Therefore, monosubstituted 1-[2-(2,4-dichlorophenyl)ethyl]-1H-imidazoles differing from tioconazole by the nature of the linker and of the aromatic ring in their side-chain were synthesized and evaluated against the mutant and the wild-type strain of C. glabrata. New 2-aryl-1-azolyl-3-thienylbutan-2-ols were then designed and synthesized, and their antifungal activity was evaluated against both strains of C. glabrata and two other major human pathogenic fungi, C. albicans and Aspergillus fumigatus. These new compounds exhibited a broad spectrum activity, as well as good efficiency against the petite mutant, suggesting that they may overcome the increased expression of the efflux pumps usually observed in clin. yeast isolates resistant to current azoles.
Journal of Enzyme Inhibition and Medicinal Chemistry published new progress about Aspergillus fumigatus. 19995-38-1 belongs to class chlorides-buliding-blocks, and the molecular formula is C6H7ClS, HPLC of Formula: 19995-38-1.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics