Pettinari, Claudio; Pettinari, Riccardo; Xhaferai, Nertil; Giambastiani, Giuliano; Rossin, Andrea; Bonfili, Laura; Maria Eleuteri, Anna; Cuccioloni, Massimiliano published the artcile< Binuclear 3,3',5,5'-tetramethyl-1H,H-4,4'-bipyrazole Ruthenium(II) complexes: Synthesis, characterization and biological studies>, Reference of 67421-02-7, the main research area is binuclear arene tetramethylbipyrazole ruthenium preparation crystal mol structure antitumor; DNA interaction binuclear arene tetramethylbipyrazole ruthenium complex.
Organometallic Ru(II) arene complexes have emerged as potential alternative to platinum anti-tumor drugs due to their stability in solution and in the solid state, significant biol. activity and reduced toxicity and hydrophobicity of their ancillary arene groups. Authors report here a series of Ru(II)-arene dinuclear complexes prepared from 3,3′,5,5′-tetramethyl-1H,H-4,4′-bipyrazole and [(η6-arene)RuCl2] dimers. The new compounds were spectroscopically (FT-IR, 1H, 13C, ESI-MS) and structurally characterized. These complexes were found to adopt the piano stool coordination geometry around the Ru(II) ions, with the bipyrazole ligand bridging two metal centers through its pyridinic nitrogen. Their in vitro cytotoxicity was paralleled in human epithelial normal, cancerous and cisplatin-resistant cancerous cells. Ultimately, two possible mechanisms of drug biochem. action underlying the observed effects (DNA targeting and proteasome inhibitory abilities) were explored.
Inorganica Chimica Acta published new progress about Antitumor agents. 67421-02-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C24H36Cl4Ru2, Reference of 67421-02-7.
Referemce:
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