Rajak, Harish; Agarawal, Avantika; Parmar, Poonam; Thakur, Bhupendra Singh; Veerasamy, Ravichandran; Sharma, Prabodh Chander; Kharya, Murli Dhar published the artcile< 2,5-Disubstituted-1,3,4-oxadiazoles/thiadiazole as surface recognition moiety: Design and synthesis of novel hydroxamic acid based histone deacetylase inhibitors>, Formula: C8H6ClN3S, the main research area is tetrahydropyranyloxy aryloxadiazolecarboxamide arylthiadiazolecarboxamide preparation histone deacetylase inhibitor antitumor.
The enzymic inhibition of histone deacetylase activity has come out as a novel and effectual means for the treatment of cancer. Two novel series of 2-[5-(4-substituted phenyl)-[1,3,4]-oxadiazol- and -thiadiazol-2-ylamino]pyrimidine-5-carboxylic acid (tetrahydropyran-2-yloxy)amides were designed and synthesized as novel hydroxamic acid based histone deacetylase inhibitors. The antiproliferative activities of the compounds were investigated in vitro using histone deacetylase inhibitory assay and MTT assay. The synthesized compounds were also tested for antitumor activity against Ehrlich ascites carcinoma cells in Swiss albino mice. Efforts were also made to establish structure-activity relationships among synthesized compounds The results of the present study indicate that these compounds are promising surface recognition moieties for development of newer hydroxamic acid based histone deacetylase inhibitor.
Bioorganic & Medicinal Chemistry Letters published new progress about Antitumor agents. 70057-67-9 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H6ClN3S, Formula: C8H6ClN3S.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics