Sarkate, Aniket P.; Shinde, Devanand B. published the artcile< Synthesis and docking studies of ethyl 4-(4-((2-(nitrooxy)ethoxy)carbonyl)phenyl)-2-substituted-6-substitutedphenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate as anti-inflammatory, analgesic and nitric oxide releasing agents>, SDS of cas: 162046-61-9, the main research area is pyrimidine derivative anti inflammatory analgesic nitric oxide.
In the present study, a series of pyrimidine derivatives (6a-6z) was synthesized and tested for its anti-inflammatory, analgesic and nitric oxide releasing activity. The main aim of this study was to develop new chem. entities as potential anti-inflammatory agents. In this article, synthesis of a series of mols. containing important pharmacophore substituted diaryl rings on 6-membered heterocycle similar to coxibs and nitric oxide releasing moiety are described. All the synthesized compounds were tested in vivo for their anti-inflammatory, analgesic studies and in vitro for their nitric oxide-releasing properties. Out of the twenty six synthesized compounds, four compounds showed significant anti-inflammatory and analgesic activity which was compared with standard All the synthesized compounds exhibited significant nitric oxide-releasing activity.
Research Journal of Pharmaceutical, Biological and Chemical Sciences published new progress about Analgesics. 162046-61-9 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H4ClF3O2, SDS of cas: 162046-61-9.
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