Shi, Guo Q.; Dropinski, James F.; Zhang, Yong; Santini, Conrad; Sahoo, Soumya P.; Berger, Joel P.; MacNaul, Karen L.; Zhou, Gaochao; Agrawal, Arun; Alvaro, Raul; Cai, Tian-Quan; Hernandez, Melba; Wright, Samuel D.; Moller, David E.; Heck, James V.; Meinke, Peter T. published the artcile< Novel 2,3-dihydrobenzofuran-2-carboxylic acids: Highly potent and subtype-selective PPARα agonists with potent hypolipidemic activity>, Reference of 35852-58-5, the main research area is hydroxydihydrobenzofurancarboxylate phenoxyalkyl iodide alkylation; phenoxyalkoxydihydrobenzofurancarboxylate preparation hydrolysis; phenoxylalkoxy dihydrobenzofurancarboxylic acid preparation PPAR ligand; dihydrobenzofurancarboxylic acid preparation phenoxylalkoxy asym preparation PPAR ligand.
The design and synthesis of a class of 2,3-dihydrobenzofuran-2-carboxylic acids, e.g., I, as highly potent and subtype-selective PPARα agonists are reported. Systematic study of structure-activity relationships has identified several key structural elements within this class for maintaining the potency and subtype selectivity. Select compounds were evaluated in animal models of dyslipidemia using Syrian hamsters and male Beagle dogs, and all these compounds displayed excellent cholesterol- and triglyceride-lowering activity at dose levels that were much lower than the marketed weak PPARα agonist fenofibrate.
Journal of Medicinal Chemistry published new progress about Alkylation. 35852-58-5 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H4ClF3O, Reference of 35852-58-5.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics