Application of 73006-78-7, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 73006-78-7, name is 5-Chloro-[1,1′-biphenyl]-2-amine, This compound has unique chemical properties. The synthetic route is as follows.
General procedure: (B) Under a nitrogen atmosphere, a 100 mL Schlenk flask was charged with 4′-(tert-butyl)-[1,1′-biphenyl]-2-amine (0.56g, 2.5 mmol) and THF (10 mL) at 0 oC with stirring. Acetic formic anhydride (2 mL), which was prepared from the reaction of acetic anhydride with formic acid (1.1 equiv) at 55 C for 2 h, was added dropwise with syringe. Then, the reaction mixture was warmed to room temperature for 2 h, treated with saturated NaHCO3, and extracted with EtOAc (3 ¡Á 25 mL). The combined organic layers were dried over anhydrous Na2SO4 and concentrated to dryness under reduced pressure. The residue was purified by column chromatography on silica gel using a mixture of petroleum ether and ethyl acetate (3:1 (v/v)) as eluents to afford N-(4′-(tert-butyl)-[1,1′-biphenyl]-2-yl)formamide as a yellow oil (0.60 g 95%).
The chemical industry reduces the impact on the environment during synthesis 5-Chloro-[1,1′-biphenyl]-2-amine. I believe this compound will play a more active role in future production and life.
Reference:
Article; Zhao, Cheng-Long; Shi, Jin; Lu, Xiuqiang; Wu, Xun; Zhang, Cheng-Pan; Journal of Fluorine Chemistry; vol. 226; (2019);,
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