《Design, synthesis, and evaluation of novel N′-substituted-1-(4-chlorobenzyl)-1H-indol-3-carbohydrazides as antitumor agents》 was published in Journal of Enzyme Inhibition and Medicinal Chemistry in 2020. These research results belong to Huan, Le Cong; Anh, Duong Tien; Hai, Pham-The; Anh, Lai Duc; Park, Eun Jae; Ji, A. Young; Kang, Jong Soon; Dung, Do Thi Mai; Oanh, Dao Thi Kim; Tung, Truong Thanh; Hai, Dinh Thi Thanh; Han, Sang-Bae; Nam, Nguyen-Hai. Computed Properties of C7H6BrCl The article mentions the following:
In continuity of our search for novel anticancer agents acting as procaspase activators, we have designed and synthesized two series of (E)-N′-benzylidene-carbohydrazides (4a-m) and (Z)-N′-(2-oxoindolin-3-ylidene)carbohydrazides (5a-g) incorporating 1-(4-chlorobenzyl)-1H-indole core. Bioevaluation showed that the compounds, especially compounds in series 4a-m,, exhibited potent cytotoxicity against three human cancer cell lines (SW620, colon cancer; PC-3, prostate cancer; NCI-H23, lung cancer). Within series , compounds with 2-OH substituent (4g-i) exhibited very strong cytotoxicity in three human cancer cell lines assayed with IC50 values in the range of 0.56-0.83 μM. In particular, two compounds 4d and 4f bearing 4-CL and 4-NO2 substituents, resp., were the most potent in term of cytotoxicity with IC50 values of 0.011-0.001 μM. In caspase activation assay, compounds 4b and 4f were found to activate caspase activity by 314.3 and 270.7% relative to PAC-1. This investigation has demonstrated the potential of these simple acetohydrazides, especially compounds 4b, 4d, and 4f as anticancer agents. In the experimental materials used by the author, we found 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Computed Properties of C7H6BrCl)
1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) is a useful reagent for the preparation of panicinotam derivatives for use as anti-inflammatory agents or immunomodulators.Computed Properties of C7H6BrCl It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.
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Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics