In 2019,Chemical Communications (Cambridge, United Kingdom) included an article by Chen, Xin-Lei; Zhou, Sheng-Hua; Lin, Jin-Hong; Deng, Qing-Hai; Xiao, Ji-Chang. Application In Synthesis of 1-(Bromomethyl)-4-chlorobenzene. The article was titled 《Difluorocarbene-derived trifluoromethylselenolation of benzyl halides》. The information in the text is summarized as follows:
Cu-Promoted difluorocarbene-derived trifluoromethylselenolation of benzyl halides RX [R = C6H5(CH2)2, naphthalen-2-ylmethyl, (3,4-dichlorophenyl)methyl, etc.; X = Cl, Br] with the Ph3P+CF2CO2-/Se/F- system is described. Three new carbon-heteroatom bonds, a Se-CF2 bond, SeCF2-F bond, and C-SeCF3 bond, were sequentially formed in the reaction. This work represents the first trifluoromethylselenolation protocol involving an external fluoride for the generation of the key intermediate, CF3Se- anion. The experimental process involved the reaction of 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Application In Synthesis of 1-(Bromomethyl)-4-chlorobenzene)
1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) is a useful reagent for the preparation of panicinotam derivatives for use as anti-inflammatory agents or immunomodulators.Application In Synthesis of 1-(Bromomethyl)-4-chlorobenzene It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics