Some common heterocyclic compound, 98446-49-2, name is 2,4-Dichloro-5-methoxyaniline, molecular formula is C7H7Cl2NO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C7H7Cl2NO
To a stirred solution of 4-chloro-5-[3-(2-chloroethoxy)phenyl]nicotinonitrile (200 mg, 0.68 mmol), 2,4-dichloro-5-methoxyaniline (196 mg, 1 mmol), 2-dicyclohexylphosphino 2′(N,N-dimethylamino)biphenyl (80 mg, 0.20 mmol), and K3PO4 (216 mg, 1 mmol) in 4 mL anhydrous ethylene glycol dimethyl ether was added Pd2(dba)3 (62 mg, 0.07 mmol). The mixture was heated to 90 C. for 2 hours then cooled, filtered through Celite, concentrated in vacuo, and purified by silica gel chromatography eluding with 5-50% MeOH in CH2Cl2 to yield 160 mg of 5-[3-(2-chloroethoxy)phenyl]-4-[(2,4-dichloro-5-methoxyphenyl)amino]nicotinonitrile 150 as a solid (52%). HPLC retention time(c): 14.29 min.; MS: 448 [M+H].
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 98446-49-2, its application will become more common.
Reference:
Patent; Cole, Derek Cecil; Asselin, Magda; Boschelli, Diane Harris; Wissner, Allan; Wang, Yanong Daniel; Prashad, Amarnauth Shastrie; Dushin, Russell; US2007/287738; (2007); A1;,
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