SDS of cas: 5781-53-3In 2022 ,《Chiral phosphoric acid-catalyzed enantioselective synthesis of pyrazole-based unnatural α-amino acid derivatives》 appeared in Advanced Synthesis & Catalysis. The author of the article were Woldegiorgis, Alemayehu Gashaw; Han, Zhao; Lin, Xufeng. The article conveys some information:
An enantioselective synthesis of unnatural pyrazole-based α-chiral amino acid derivatives from the asym. reaction of N-aryl-5-aminopyrazoles with β,γ-alkynyl-α-imino esters using a chiral spirocyclic phosphoric acid catalyst was developed. Using the established methodol., various pyrazole-based α-amino acid derivatives with tetrasubstituted carbon stereocenters were obtained in 67-98% yields and with 73-99% enantioselectivities. The NH2 functionality in the corresponding products enables further transformations to a chiral thiourea and a lactam.Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3SDS of cas: 5781-53-3) was used in this study.
Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3) belongs to acyl chlorides. Lacking the ability to form hydrogen bonds, acyl chlorides have lower boiling and melting points than similar carboxylic acids. For example, acetic acid boils at 118 °C, whereas acetyl chloride boils at 51 °C. Like most carbonyl compounds, infrared spectroscopy reveals a band near 1750 cm−1.SDS of cas: 5781-53-3
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics