In 2022,Zheng, Yu; He, Xian-Chen; Gao, Jie; Xie, Zhen-Zhen; Wang, Zhi-Wei; Liu, Zhi-Lin; Chen, Kai; Xiang, Hao-Yue; Chen, Xiao-Qing; Yang, Hua published an article in Chemical Communications (Cambridge, United Kingdom). The title of the article was 《Programmable iodization/deuterolysis sequences of phosphonium ylides to access deuterated benzyl iodides and aromatic aldehydes》.Electric Literature of C7H6BrCl The author mentioned the following in the article:
A tunable iodization/deuterolysis protocol for phosphonium ylides by employing D2O as the deuterium source were designed. Notably, this process was manipulated by tuning the base, thus leading to two valuable deuterated building blocks – benzyl iodides and aromatic aldehydes with broad substrate scope, good functional group compatibility and excellent deuteration degree. Concise syntheses of a series of deuterated drug analogs was achieved based on the developed deuteration reaction platform. In addition to this study using 1-(Bromomethyl)-4-chlorobenzene, there are many other studies that have used 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Electric Literature of C7H6BrCl) was used in this study.
1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) is a useful reagent for the preparation of panicinotam derivatives for use as anti-inflammatory agents or immunomodulators.Electric Literature of C7H6BrCl It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics