Reference of Benzylidenebis(tricyclohexylphosphine)dichlororutheniumIn 2020 ,《Cell Engineering with Functional Poly(oxanorbornene) Block Copolymers》 appeared in Angewandte Chemie, International Edition. The author of the article were Church, Derek C.; Pokorski, Jonathan K.. The article conveys some information:
Cell-based therapies are gaining prominence in treating a wide variety of diseases and using synthetic polymers to manipulate these cells provides an opportunity to impart function that could not be achieved using solely genetic means. Herein, we describe the utility of functional block copolymers synthesized by ring-opening metathesis polymerization (ROMP) that can insert directly into the cell membrane via the incorporation of long alkyl chains into a short polymer block leading to non-covalent, hydrophobic interactions with the lipid bilayer. Furthermore, we demonstrate that these polymers can be imbued with advanced functionalities. A photosensitizer was incorporated into these polymers to enable spatially controlled cell death by the localized generation of 1O2 at the cell surface in response to red-light irradiation In a broader context, we believe our polymer insertion strategy could be used as a general methodol. to impart functionality onto cell-surfaces.Benzylidenebis(tricyclohexylphosphine)dichlororuthenium(cas: 172222-30-9Reference of Benzylidenebis(tricyclohexylphosphine)dichlororuthenium) was used in this study.
Benzylidenebis(tricyclohexylphosphine)dichlororuthenium(cas: 172222-30-9) is the first metathesis catalyst to be widely used in organic synthesis. It is useful for acyclic diene metathesis polymerization (ADMET), Ring-Opening Metathesis Polymerization (ROMP) of strained cyclic olefins, ring opening metathesis (ROM), and so on.Reference of Benzylidenebis(tricyclohexylphosphine)dichlororuthenium
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics