The author of 《4-(1-benzyl-1H-benzo[d]imidazol-2-yl)-4-oxo-2-butenoic acid derivatives: design, synthesis and anti-HIV-1 activity》 were Karimi, Nafiseh; Roudsari, Rouhollah Vahabpour; Movahed, Mahsa Azami; Hajimahdi, Zahra; Zarghi, Afshin. And the article was published in Iranian Journal of Pharmaceutical Research in 2021. Category: chlorides-buliding-blocks The author mentioned the following in the article:
Integrase, targeted in highly active antiretroviral therapy (HAART), was a crucial enzyme in viral replication. In this study, new benzimidazolyl diketo acid derivatives I [R = Ph, 2-MeC6H4, 2-FC6H4, etc.] were designed according to required features for inhibitors of HIV-1 integrase. Designed compounds I were evaluated for anti-HIV-1 effects and docking studies indicated that the binding mode of compound I [R = 2-FC6H4] was similar to INSTIs. According to the cell-based biol. assay’s results, most of the tested compounds I demonstrated good anti-HIV-1 activity, ranging from 40-90μM concentration with no severe cytotoxicity. In addition to this study using 3-Chlorobenzylchloride, there are many other studies that have used 3-Chlorobenzylchloride(cas: 620-20-2Category: chlorides-buliding-blocks) was used in this study.
3-Chlorobenzylchloride(cas: 620-20-2) has been used in the reaction of 3-methoxybenzyl chloride and ethyl 4-bromobenzoate in pure water, using zinc dust and a Pd catalyst.Category: chlorides-buliding-blocks
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics