《Synthesis and antibacterial activity of some new 1,2,4-triazole derivatives bearing carbohydrazide moiety》 was written by Al-Sa’Doni, Haitham Husein; Delmani, Fatima-Azzahra; Al Balushi, Abdullah Mohammed; Al-Ahmad, Ala’A. Hamed; Alsawakhneh, Sondos Omar; Al-Soud, Yaseen Ahmad. HPLC of Formula: 16629-19-9This research focused ontriazolyl carbohydrazide preparation antibacterial activity; thione triazolyl preparation antibacterial activity. The article conveys some information:
In this study, a series of 1,2,4-triazol-3-carbohydrazide derivatives like 3-methoxy-benzoic acid N'[2-(1,5-diethyl-1H-[1,2,4]triazole3-yl)-acetyl]-hydrazide, 3,5-dinitro-benzoic acid N'[2-(1, 5-diethyl-1H-[1, 2, 4]triazole-3-yl)-acetyl]-hydrazide and compound of 1,2,4- triazole-3-(4H)-thion I (R = C6H5, 2-thienyl, 7-methoxy-4-methyl-2-oxo-2H-chromen-6-yl; R1 = Me, Et; R2 = Et) have been synthesized. Structures and purity of the new compounds I were confirmed by the use of their chromatog. and spectral data besides microanal. Four different bacterial stains for the study of the biol. activity of compounds I (R = 2,5-(Cl)2C6H3, R1 = Me, R2 = Et; R = 3-CF3C6H4, R1 = Et, R2 = Et; R = 2,5-(Cl)2C6H3, R1 = Et, R2 = Et; R = 2-thienyl, R1 = Et, R2 = Et); two Gram-pos. strains, and two Gram-neg. strains have been used. Compound I (R = 2,5-(Cl)2C6H3, R1 = Me, R2 = Et) was found to be the most active of the four tested compounds against Pseudomonas aeruginosa, Bacillus cereus and Staphylococcus aureus, with an inhibition zone diameter of 16, 9, and 10 mm, resp. Calculating the minimal inhibitory concentration value (MIC) for the pos. drugs which formed an inhibition zone in the agar well diffusion method, it was found that both I (R = 2,5-(Cl)2C6H3, R1 = Me, R2 = Et; R = 2-thienyl, R1 = Et, R2 = Et) were the most active of the four tested compounds against Pseudomonas aeruginosa and Bacillus cereus with an MIC value of 0.5μg/mL for both bacteria. These results suggest that these two compounds I (R = 2,5-(Cl)2C6H3, R1 = Me, R2 = Et; R = 2-thienyl, R1 = Et, R2 = Et) could be considered as potential antibacterial agents against a range of bacteria. In the part of experimental materials, we found many familiar compounds, such as Thiophene-2-sulfonyl chloride(cas: 16629-19-9HPLC of Formula: 16629-19-9)
Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. HPLC of Formula: 16629-19-9
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Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics