Javed, Erman; Guthrie, Jacob D.; Neu, Justin; Chirayath, George S.; Huo, Shouquan published the artcile< Introducing an α-Keto Ester Functional Group through Pt-Catalyzed Direct C-H Acylation with Ethyl Chlorooxoacetate>, Recommanded Product: 4-Chloro-2-methoxyphenol, the main research area is aryloxy pyridine chlorooxoacetate platinum catalyst regioselective acylation; aryl oxoacetate preparation.
Platinum-catalyzed selective C-H acylation of 2-aryloxypyridines with Et chlorooxoacetate provided an efficient way of introducing an α-keto ester functional group. The reaction is oxidant-free, additive-free and more significantly free of any decarbonylative side reactions. The reaction tolerated a variety of substituents from strongly electron-donating to strongly electron-withdrawing groups. Double acylation was feasible for 2-phenoxypyridine and its derivatives with only one substituent at the para position. Although the reaction of 2-(2-methylphenoxy)pyridine with Et malonyl chloride did not produce the desired β-keto ester, the reaction with Et succinyl chloride proceeded smoothly to give the γ-keto ester. Et chlorooxoacetate was much more reactive than Et succinyl chloride in this Pt-catalyzed C-H acylation reaction.
ACS Omega published new progress about Acylation catalysts (regioselective). 16766-30-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H7ClO2, Recommanded Product: 4-Chloro-2-methoxyphenol.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics