627-42-9, A common compound: 627-42-9, name is 2-Methoxyethyl chloride, belongs to chlorides-buliding-blocks compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below.
The ether-functionalized ionic liquids 1-(2-methoxyethyl)-3-methylimidazolium threonine ([C1OC2Mim][Thr]) and 1-(2-ethoxyethyl)-3-methylimidazolium threonine ([C2OC2Mim][Thr]) were prepared according to the method as described in the literatures [32]. Under the protection of nitrogen, 2-chloroethyl methyl ether (122 ml, 1.1 mol) was added to N-methylimidazole (85 ml,1.0 mol) with a constant pressure funnel in round-bottom flaskwas stirred at 353.15 K for 48 h. After the reaction, extraction with ethyl acetate (3 ¡Á 60 mL) and drying under vacuum at 353.15 K for48 h to obtain pale yellow liquid [C1OC2Mim][Cl]. Next,[C1OC2Mim][OH] was synthesized from [C1OC2mim][Cl] by the useof activated anion-exchange resin. Then aqueous [C1OC2Mim][OH] was added to a slightly excess threonine aqueous solution and stirred for 48 h. Finally, excess water was evaporated under reduced pressure. To this reaction mixture was added the mixed solvent ethanol/acetonitrile (volumetric ratio = 9/1), and it was stirred befittingly. The mixture was then filtered to remove excess threonine.The product was dried under vacuum at 353.15 K for 48 h to obtain the target ionic liquid [C1OC2Mim][Thr]. Similarly, [C2OC2Mim] [Thr] was also synthesized according to the above method. Fig. 1 shows the synthetic route of the ionic liquids [C1OC2Mim][Thr] and [C2OC2Mim][Thr]. Based on the mass loss of product, the yields were estimated approximately 80%. The ether groups are abbreviated as CmOCn-, where m stands for the number of carbon atoms inthe alkyl tail and n stands for the number of carbon atoms of the spacer between the cationic nitrogen atom and the ether oxygen atom. The 3-methylimidazolium and the threonine are abbreviated as Mim and Thr, respectively.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Methoxyethyl chloride, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Zhang, Duo; Li, Biao; Hong, Mei; Kong, Yu-Xia; Tong, Jing; Xu, Wei-Guo; Journal of Molecular Liquids; vol. 304; (2020);,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics