Rambo, Raoni S.; Waldow, Etienne C.; Abaddi, Bruno L.; Silveira, Maiele D.; Dadda, Adilio S.; Sperotto, Nathalia; Bizarro, Cristiano V.; Basso, Luiz Augusto; Machado, Pablo published their research in Journal of the Brazilian Chemical Society in 2021. The article was titled 《Design, synthesis and antitubercular activity of 2-(benzylthio)-1H-benzo[d]imidazoles》.Application of 622-95-7 The article contains the following contents:
Using mol. simplification and mol. hybridization approaches, a series of 2-(benzylthio)-1H-benzo[d]imidazoles I [R = H, MeO; R1 = H, F, 3,4-(Cl)2, etc.] was synthesized and evaluated as in-vitro inhibitors of Mycobacterium tuberculosis (M. tuberculosis) growth. Compounds I [R = H, MeO; R1 = 3,5-(NO)2] were considered the lead compounds from this series of mols., with minimal inhibitory concentration (MIC) values of 6.9 and 3.8μM against M. tuberculosis H37Rv, resp. Addnl., the leading compounds were active against multidrug-resistant strains and were devoid of apparent toxicity to Vero and HepG2 cells, from 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and neutral red assays. Finally, the compounds I presented good aqueous solubility and high plasma stability. These data together indicated that this class of mols. may furnish new anti-tuberculosis drug candidates for future development. In addition to this study using 1-(Bromomethyl)-4-chlorobenzene, there are many other studies that have used 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Application of 622-95-7) was used in this study.
1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) may be used to synthesize 1-(4-chlorobenzyl)-2-(pyrrolidin-1-yl-methyl)-1H-benzimidazole dihydrochloride.Application of 622-95-7 It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics