Boehm, Philip; Martini, Tristano; Lee, Yong Ho; Cacherat, Bastien; Morandi, Bill published an article in Angewandte Chemie, International Edition. The title of the article was 《Palladium-Catalyzed Decarbonylative Iodination of Aryl Carboxylic Acids Enabled by Ligand-Assisted Halide Exchange》.HPLC of Formula: 6313-54-8 The author mentioned the following in the article:
An efficient and broadly applicable palladium-catalyzed iodination of inexpensive and abundant aryl and vinyl carboxylic acids via in situ activation to the acid chloride and formation of a phosphonium salt is reported. The use of 1-iodobutane as iodide source in combination with a base and a deoxychlorinating reagent gives access to a wide range of aryl and vinyl iodides under Pd/Xantphos catalysis, including complex drug-like scaffolds. Stoichiometric experiments and kinetic anal. suggest a unique mechanism involving C-P reductive elimination to form the Xantphos phosphonium chloride, which subsequently initiates an unusual halogen exchange by outer sphere nucleophilic substitution. In the experiment, the researchers used 2-Chloroisonicotinic acid(cas: 6313-54-8HPLC of Formula: 6313-54-8)
2-Chloroisonicotinic acid(cas: 6313-54-8) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.HPLC of Formula: 6313-54-8
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics