Yang, Chao; Gao, Yadong; Bai, Songlin; Jiang, Chao; Qi, Xiangbing published an article in Journal of the American Chemical Society. The title of the article was 《Chemoselective Cross-Coupling of gem-Borazirconocene Alkanes with Aryl Halides》.Synthetic Route of C18H24Cl2N2Pd2 The author mentioned the following in the article:
The direct and chemoselective conversion of the C-metal bond of gem-dimetallic reagents enables rapid and sequential formation of multiple C-C and C-heteroatom bonds, thus representing a powerful method for efficiently increasing structural complexity. Herein, the authors report a visible-light-induced, Ni-catalyzed, chemoselective cross-coupling reaction between gem-borazirconocene alkanes and diverse aryl halides, affording a wide range of alkyl Bpin derivatives in high yields with excellent regioselectivity. This practical method features attractively simple reaction conditions and a broad substrate scope. Addnl., the authors systematically studied a Bpin-directed chain walking process underlying the regioselectivity of alkylzirconocenes, thus uncovering the mechanism of the remote functionalization of internal olefins achieved with the authors’ method. Finally, DFT calculations indicate that the high regioselectivity of this reaction originates from the directing effect of the Bpin group. In the experiment, the researchers used Di-μ-chlorobis[2-[(dimethylamino)methyl]phenyl-C,N]dipalladium(II)(cas: 18987-59-2Synthetic Route of C18H24Cl2N2Pd2)
Di-μ-chlorobis[2-[(dimethylamino)methyl]phenyl-C,N]dipalladium(II)(cas: 18987-59-2) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Synthetic Route of C18H24Cl2N2Pd2
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics